药源性肝损害与HLA基因多态性的相关性研究进展

毛俊俊,,焦正 * ,钟明康,蔡卫民

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (10) : 806-811.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (10) : 806-811. DOI: 10.11669/cpj.2014.10.002
综述

药源性肝损害与HLA基因多态性的相关性研究进展

  • 毛俊俊1,2,焦正1 * ,钟明康1,蔡卫民2
作者信息 +

Advance on the Association of Drug-induced Liver Injury and HLA Gene Polymorphism

  • MAO Jun-jun1,2,JIAO Zheng1*,ZHONG Ming-kang1,CAI Wei-min2
Author information +
文章历史 +

摘要

目的 综述药源性肝损害与人类白细胞抗原(human leucocyte antigen,HLA)基因相关性研究成果及进展。方法 查阅近年来国内外相关文献,对药源性肝损害药物及相关人类白细胞抗原等位基因进行归纳总结。结果与结论 人类白细胞抗原基因与药源性肝损害之间有很强的遗传相关性,如HLA-B*5701与氟氯西林引起药源性肝损害高度相关(相对危险度=80.6)。奈韦拉平、噻氯匹定、希美加群引起药源性肝损害相关的人类白细胞抗原等位基因在不同人群中携带频率不同。因此,该不良反应发生率存在种族差异。相关研究有助于深入了解免疫因素在药源性肝损害发生机制中的作用,对发现相应基因生物标志物、提高用药安全性、实现个体化治疗具有重要意义。

Abstract

OBJECTIVE To review and summarize the progress in the genetic association studies between human leucocyte antigen(HLA) polymorphisms and drug-induced liver injury(DILI). METHODS Based on the literature research, the results of the studies on the association between HLA alleles and DILI are presented and evaluated. RESULTS AND CONCLUSION Several strong genetic associations between DILI and HLA alleles were observed in previous studies, such as HLA-B*5701 has a strong association with flucloxacillin induced liver injury (odds ratio=80.6).Due to the racial differences in HLA alleles frequency, the incidence of DILI by nevirapine, ticlopidine, ximelagatran varied largely in different ethnic populations. These studies can help us better understand the immunogenic pathogenesis in the underlying mechanism of DILI. The discovery of genetic biomarkers can be developed as a predictive test will improve drug safety and facilitate the individual therapy

关键词

药源性肝损害 / 人类白细胞抗原 / 药物基因组学 / 生物标志物 / 个体化治疗

Key words

drug-induced liver injury / human leucocyte antigen / pharmacogenomics / biomarker / individualized therapy

引用本文

导出引用
毛俊俊,,焦正 * ,钟明康,蔡卫民. 药源性肝损害与HLA基因多态性的相关性研究进展[J]. 中国药学杂志, 2014, 49(10): 806-811 https://doi.org/10.11669/cpj.2014.10.002
MAO Jun-jun,,JIAO Zheng*,ZHONG Ming-kang,CAI Wei-min. Advance on the Association of Drug-induced Liver Injury and HLA Gene Polymorphism[J]. Chinese Pharmaceutical Journal, 2014, 49(10): 806-811 https://doi.org/10.11669/cpj.2014.10.002
中图分类号: R96   

参考文献

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